Version 5.4
Homo sapiens Protein: SAC3D1
Summary
InnateDB Protein IDBP-232101.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAC3D1
Protein Name SAC3 domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381824
InnateDB Gene IDBG-56231 (SAC3D1)
Protein Structure
UniProt Annotation
Function Involved in centrosome duplication and mitotic progression. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes on centrosomes in interphase cells and at spindles in mitosis. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0046426 negative regulation of JAK-STAT cascade
GO:0050776 regulation of immune response
GO:0051225 spindle assembly
GO:0051298 centrosome duplication
Cellular Component
GO:0005634 nucleus
GO:0005813 centrosome
GO:0005819 spindle
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR005062 SAC3/GANP/Nin1/mts3/eIF-3 p25
PFAM PF03399
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-A6NKF1
TrEMBL F8WC89
UniProt Splice Variant
Entrez Gene 29901
UniGene Hs.23642
RefSeq NP_037431
HUGO HGNC:30179
OMIM
CCDS CCDS41668
HPRD 11558
IMGT
EMBL AP003068
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca