InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MX1

Summary

InnateDB Protein

IDBP-232613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MX1

Protein Name

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

Synonyms

IFI-78K; IFI78; MX; MxA;

Species

Homo sapiens

Ensembl Protein

ENSP00000381601

InnateDB Gene

IDBG-3941 (MX1)

Protein Structure

UniProt Annotation

Function

Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. {ECO:0000269PubMed:11880649, ECO:0000269PubMed:14687945, ECO:0000269PubMed:14752052, ECO:0000269PubMed:15047845, ECO:0000269PubMed:15355513, ECO:0000269PubMed:15757897, ECO:0000269PubMed:16202617, ECO:0000269PubMed:16413306, ECO:0000269PubMed:17374778, ECO:0000269PubMed:18668195, ECO:0000269PubMed:19109387, ECO:0000269PubMed:21900240, ECO:0000269PubMed:21992152}.

Subcellular Localization

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region.Isoform 2: Cytoplasm {ECO:0000269PubMed:20603636}. Nucleus {ECO:0000269PubMed:20603636}. Note=Translocates into the nuclei of HSV-1 infected cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006915	apoptotic process
GO:0006952	defense response
GO:0007165	signal transduction
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0034340	response to type I interferon
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt