InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPYSL3

Summary

InnateDB Protein

IDBP-232910.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYSL3

Protein Name

dihydropyrimidinase-like 3

Synonyms

CRMP-4; CRMP4; DRP-3; DRP3; LCRMP; ULIP; ULIP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000381526

InnateDB Gene

IDBG-52219 (DPYSL3)

Protein Structure

UniProt Annotation

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0017124	SH3 domain binding
GO:0035374	chondroitin sulfate binding

Biological Process

GO:0006208	pyrimidine nucleobase catabolic process
GO:0007411	axon guidance
GO:0008152	metabolic process
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0030336	negative regulation of cell migration
GO:0048678	response to axon injury
GO:0051017	actin filament bundle assembly
GO:0051260	protein homooligomerization
GO:0051491	positive regulation of filopodium assembly
GO:0051764	actin crosslink formation
GO:0071345	cellular response to cytokine stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030027	lamellipodium
GO:0030426	growth cone
GO:0031941	filamentous actin
GO:0044297	cell body
GO:0070382	exocytic vesicle