Homo sapiens Protein: ABCG1
InnateDB Protein IDBP-232963.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCG1
Protein Name ATP-binding cassette, sub-family G (WHITE), member 1
Synonyms ABC8; WHITE1;
Species Homo sapiens
Ensembl Protein ENSP00000381475
InnateDB Gene IDBG-4231 (ABCG1)
Protein Structure
UniProt Annotation
Function Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:22042635}. Endoplasmic reticulum membrane {ECO:0000269PubMed:22042635}; Multi-pass membrane protein {ECO:0000269PubMed:22042635}. Golgi apparatus membrane {ECO:0000269PubMed:22042635}; Multi-pass membrane protein {ECO:0000269PubMed:22042635}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
Disease Associations
Tissue Specificity Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. {ECO:0000269PubMed:11350058}.
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005548 phospholipid transporter activity
GO:0015485 cholesterol binding
GO:0016887 ATPase activity
GO:0017127 cholesterol transporter activity
GO:0019534 toxin transporter activity
GO:0034041 sterol-transporting ATPase activity
GO:0034437 glycoprotein transporter activity
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0008203 cholesterol metabolic process
GO:0009720 detection of hormone stimulus
GO:0010033 response to organic substance
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010872 regulation of cholesterol esterification
GO:0010887 negative regulation of cholesterol storage
GO:0032367 intracellular cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0033993 response to lipid
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034436 glycoprotein transport
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0042987 amyloid precursor protein catabolic process
GO:0043691 reverse cholesterol transport
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0055085 transmembrane transport
GO:0055091 phospholipid homeostasis
GO:1901998 toxin transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0055037 recycling endosome
Protein Structure and Domains
InterPro IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005284 Pigment precursor permease
IPR013525 ABC-2 type transporter
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00005
Post-translational Modifications
SwissProt P45844
PhosphoSite PhosphoSite-P45844
TrEMBL O43576
UniProt Splice Variant
Entrez Gene 9619
UniGene Hs.714136
RefSeq NP_997511
OMIM 603076
HPRD 04355
EMBL AB038161 AF038175 AF323640 AF323642 AF323643 AF323644 AF323645 AF323646 AF323647 AF323648 AF323649 AF323650 AF323651 AF323652 AF323653 AF323654 AF323655 AF323656 AF323657 AF323658 AF323660 AF323661 AF323662 AF323663 AF323664 AJ289137 AJ289138 AJ289139 AJ289140 AJ289141 AJ289142 AJ289143 AJ289144 AJ289145 AJ289146 AJ289147 AJ289148 AJ289149 AJ289150 AJ289151 AP001746 AY048757 BC029158 U34919 X91249
GenPept AAB97364 AAC51098 AAH29158 AAK28833 AAK28834 AAK28835 AAK28836 AAK28837 AAK28838 AAK28839 AAK28840 AAK28841 AAK28842 AAL06598 BAA95530 BAB13728 CAA62631 CAC00730