InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCG1

Summary

InnateDB Protein

IDBP-232963.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCG1

Protein Name

ATP-binding cassette, sub-family G (WHITE), member 1

Synonyms

ABC8; WHITE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000381475

InnateDB Gene

IDBG-4231 (ABCG1)

Protein Structure

UniProt Annotation

Function

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:22042635}. Endoplasmic reticulum membrane {ECO:0000269PubMed:22042635}; Multi-pass membrane protein {ECO:0000269PubMed:22042635}. Golgi apparatus membrane {ECO:0000269PubMed:22042635}; Multi-pass membrane protein {ECO:0000269PubMed:22042635}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.

Disease Associations

Tissue Specificity

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. {ECO:0000269PubMed:11350058}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0005548	phospholipid transporter activity
GO:0015485	cholesterol binding
GO:0016887	ATPase activity
GO:0017127	cholesterol transporter activity
GO:0019534	toxin transporter activity
GO:0034041	sterol-transporting ATPase activity
GO:0034437	glycoprotein transporter activity
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0008203	cholesterol metabolic process
GO:0009720	detection of hormone stimulus
GO:0010033	response to organic substance
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010872	regulation of cholesterol esterification
GO:0010887	negative regulation of cholesterol storage
GO:0032367	intracellular cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0033993	response to lipid
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034436	glycoprotein transport
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0042987	amyloid precursor protein catabolic process
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0055085	transmembrane transport
GO:0055091	phospholipid homeostasis
GO:1901998	toxin transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005739	mitochondrion
GO:0005768	endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR005284 Pigment precursor permease
IPR013525 ABC-2 type transporter
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF01061

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P45844