Version 5.4
Homo sapiens Protein: ADAM22
Summary
InnateDB Protein IDBP-233513.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM22
Protein Name ADAM metallopeptidase domain 22
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381260
InnateDB Gene IDBG-25323 (ADAM22)
Protein Structure
UniProt Annotation
Function Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269PubMed:12589811, ECO:0000269PubMed:15882968, ECO:0000269PubMed:16385342}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. {ECO:0000269PubMed:16385342}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007417 central nervous system development
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
PFAM PF01421
PF00200
PF01562
PF08516
PRINTS PR00289
PIRSF
SMART SM00050
SM00608
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P0K1
PhosphoSite PhosphoSite-Q9P0K1
TrEMBL Q9UKK0
UniProt Splice Variant
Entrez Gene 53616
UniGene Hs.730222
RefSeq NP_068367
HUGO HGNC:201
OMIM 603709
CCDS CCDS43610
HPRD 04751
IMGT
EMBL AB009671 AC004992 AC005075 AC005164 AF073291 AF155381 AF155382 AF158637 AF158642 CH471091
GenPept AAD55251 AAD55253 AAF22476 AAF73288 AAF73289 AAP21878 AAS07417 BAA32349 BAA32350 EAW76913 EAW76915 EAW76917 EAW76918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca