Version 5.4
Homo sapiens Protein: CCNB1IP1
Summary
InnateDB Protein IDBP-233688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNB1IP1
Protein Name cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000381235
InnateDB Gene IDBG-2158 (CCNB1IP1)
Protein Structure
UniProt Annotation
Function Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL- gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000250}.E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Subcellular Localization Nucleus. Chromosome. Note=Associates to the synaptonemal complex.
Disease Associations
Tissue Specificity Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung. {ECO:0000269PubMed:12612082}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0007131 reciprocal meiotic recombination
GO:0016567 protein ubiquitination
GO:0051026 chiasma assembly
Cellular Component
GO:0000795 synaptonemal complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPC3
PhosphoSite PhosphoSite-Q9NPC3
TrEMBL G3V5S3
UniProt Splice Variant
Entrez Gene 57820
UniGene Hs.619532
RefSeq
HUGO HGNC:19437
OMIM 608249
CCDS CCDS9547
HPRD 07000
IMGT
EMBL AF216381 AK026233 AL161994 AL355075 AL356019 BC000369 BC001218 BC004435 BX161423 BX161424 BX247978
GenPept AAF36386 AAH00369 AAH01218 AAH04435 BAB15403 CAB82326 CAD61896 CAD61897 CAD62312

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca