Version 5.4
Homo sapiens Protein: PACS2
Summary
InnateDB Protein IDBP-23396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PACS2
Protein Name phosphofurin acidic cluster sorting protein 2
Synonyms PACS-2; PACS1L;
Species Homo sapiens
Ensembl Protein ENSP00000321834
InnateDB Gene IDBG-23394 (PACS2)
Protein Structure
UniProt Annotation
Function Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. {ECO:0000269PubMed:15692563, ECO:0000269PubMed:15692567}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000269PubMed:15692567}. Mitochondrion {ECO:0000269PubMed:15692567}.
Disease Associations
Tissue Specificity Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis. {ECO:0000269PubMed:15692567}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
GO:0016032 viral process
GO:0072661 protein targeting to plasma membrane
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR019381 Phosphofurin acidic cluster sorting protein 1
PFAM PF10254
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86VP3
PhosphoSite PhosphoSite-Q86VP3
TrEMBL F8W0V0
UniProt Splice Variant
Entrez Gene 23241
UniGene
RefSeq NP_056012
HUGO HGNC:23794
OMIM 610423
CCDS CCDS32168
HPRD 17816
IMGT
EMBL AB011174 AL512355 AL928654 AY320284 BC010663 BC050351 BC065220 BC131591
GenPept AAH10663 AAH50351 AAH65220 AAI31592 AAQ83882 BAA25528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca