InnateDB Protein
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IDBP-235117.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NANOS3
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Protein Name
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nanos homolog 3 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380687
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InnateDB Gene
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IDBG-32399 (NANOS3)
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Protein Structure
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Function |
Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269PubMed:21421998}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:21421998}. Cytoplasm {ECO:0000269PubMed:21421998}. Cytoplasmic granule {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Colocalizes with DCP1A in the P-body (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids. {ECO:0000269PubMed:21421998}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR024161
Zinc finger, nanos-type
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PFAM |
PF05741
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P60323
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PhosphoSite |
PhosphoSite-P60323
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
342977
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UniGene |
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RefSeq |
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HUGO |
HGNC:22048
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OMIM |
608229
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC020916
BC101209
BC101210
BM702754
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GenPept |
AAI01210
AAI01211
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