Version 5.4
Homo sapiens Protein: GPR18
Summary
InnateDB Protein IDBP-235325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR18
Protein Name G protein-coupled receptor 18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380613
InnateDB Gene IDBG-46091 (GPR18)
Protein Structure
UniProt Annotation
Function Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. {ECO:0000269PubMed:16844083}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells. {ECO:0000269PubMed:16844083}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14330
PhosphoSite PhosphoSite-Q14330
TrEMBL Q5JUH9
UniProt Splice Variant
Entrez Gene 2841
UniGene Hs.741589
RefSeq NP_005283
HUGO HGNC:4472
OMIM 602042
CCDS CCDS9491
HPRD 03621
IMGT
EMBL AF261135 AL160155 BC008569 BC050646 BC066927 BT009907 CH471085 JQ308176 L42324
GenPept AAB65819 AAG44671 AAH08569 AAH50646 AAH66927 AAP88909 AFF59486 CAI14306 EAX09017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca