InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD151

Summary

InnateDB Protein

IDBP-235409.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD151

Protein Name

CD151 molecule (Raph blood group)

Synonyms

GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24;

Species

Homo sapiens

Ensembl Protein

ENSP00000380565

InnateDB Gene

IDBG-18403 (CD151)

Protein Structure

UniProt Annotation

Function

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. {ECO:0000269PubMed:15265795}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD) [MIM:609057]: A disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor. {ECO:0000269PubMed:15265795}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes. {ECO:0000269PubMed:15265795}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0016477	cell migration
GO:0030198	extracellular matrix organization
GO:0031581	hemidesmosome assembly
GO:0034329	cell junction assembly
GO:0042098	T cell proliferation