InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AJUBA

Summary

InnateDB Protein

IDBP-235460.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AJUBA

Protein Name

jub, ajuba homolog (Xenopus laevis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000380543

InnateDB Gene

IDBG-2966 (AJUBA)

Protein Structure

UniProt Annotation

Function

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell- cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1- induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269PubMed:12417594, ECO:0000269PubMed:13678582, ECO:0000269PubMed:15870274, ECO:0000269PubMed:16413547, ECO:0000269PubMed:17909014, ECO:0000269PubMed:18805794, ECO:0000269PubMed:20303269, ECO:0000269PubMed:20616046, ECO:0000269PubMed:22286099}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, P-body. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase. Preferentially co- localizes with cadherin-adhesive complexes at sites of cell-cell contacts. Colocalizes with GFI1 in the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0045294	alpha-catenin binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001666	response to hypoxia
GO:0006351	transcription, DNA-templated
GO:0031334	positive regulation of protein complex assembly
GO:0035195	gene silencing by miRNA
GO:0035331	negative regulation of hippo signaling
GO:1900037	regulation of cellular response to hypoxia
GO:2000637	positive regulation of gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction