InnateDB Protein
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IDBP-235563.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ACIN1
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Protein Name
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apoptotic chromatin condensation inducer 1
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Synonyms
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ACINUS; ACN; fSAP152;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000380502
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InnateDB Gene
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IDBG-3055 (ACIN1)
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Protein Structure
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Function |
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence- independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269PubMed:10490026, ECO:0000269PubMed:12665594, ECO:0000269PubMed:18559500, ECO:0000269PubMed:22203037, ECO:0000269PubMed:22388736}.
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Subcellular Localization |
Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
93
[view]
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Protein-Protein |
92
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UKV3
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PhosphoSite |
PhosphoSite-Q9UKV3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22985
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UniGene |
Hs.124490
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RefSeq |
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HUGO |
HGNC:17066
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OMIM |
604562
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CCDS |
CCDS53887
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HPRD |
05191
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IMGT |
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EMBL |
AB014570
AF124726
AF124727
AF124728
AL050382
AL117258
AL132780
BC140805
BX247975
CH471078
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GenPept |
AAD56724
AAD56725
AAD56726
AAI40806
BAA31645
CAB43681
CAD62309
EAW66187
EAW66188
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