InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNF

Summary

InnateDB Protein

IDBP-236171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNF

Protein Name

cyclin F

Synonyms

FBX1; FBXO1;

Species

Homo sapiens

Ensembl Protein

ENSP00000380256

InnateDB Gene

IDBG-10480 (CCNF)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. {ECO:0000269PubMed:20596027}.

Subcellular Localization

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:7813445}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000320	re-entry into mitotic cell cycle
GO:0001890	placenta development
GO:0007067	mitotic nuclear division
GO:0010826	negative regulation of centrosome duplication
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process