InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA4

Summary

InnateDB Protein

IDBP-236253.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA4

Protein Name

integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Synonyms

CD49D; IA4;

Species

Homo sapiens

Ensembl Protein

ENSP00000380227

InnateDB Gene

IDBG-76684 (ITGA4)

Protein Structure

UniProt Annotation

Function

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. {ECO:0000269PubMed:19064666}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 499 experimentally validated interaction(s) in this database.

Experimentally validated
Total	499 [view]
Protein-Protein	498 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0016477	cell migration
GO:0030183	B cell differentiation
GO:0030198	extracellular matrix organization
GO:0050776	regulation of immune response
GO:0050900	leukocyte migration
GO:0060324	face development
GO:0060710	chorio-allantoic fusion
GO:0072678	T cell migration
GO:0090074	negative regulation of protein homodimerization activity

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome