Version 5.4
Homo sapiens Protein: TM9SF1
Summary
InnateDB Protein IDBP-236616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TM9SF1
Protein Name transmembrane 9 superfamily member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380063
InnateDB Gene IDBG-3649 (TM9SF1)
Protein Structure
UniProt Annotation
Function Plays an essential role in autophagy. {ECO:0000269PubMed:19029833}.
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:19029833}; Multi-pass membrane protein {ECO:0000269PubMed:19029833}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269PubMed:19029833}; Multi-pass membrane protein {ECO:0000269PubMed:19029833}.
Disease Associations
Tissue Specificity Expressed in lung, pancreas, kidney, liver, placenta, skeletal muscle, heart and brain. The amount in skeletal muscle, heart and brain were considerably lower than in the other tissues. {ECO:0000269PubMed:9332367}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006914 autophagy
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR004240 Nonaspanin (TM9SF)
PFAM PF02990
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15321
PhosphoSite PhosphoSite-O15321
TrEMBL E9PS99
UniProt Splice Variant
Entrez Gene 10548
UniGene Hs.91586
RefSeq NP_001014842
HUGO HGNC:11864
OMIM
CCDS CCDS41934
HPRD 09987
IMGT
EMBL AL096870 AL136295 BC010856 BX161390 BX161494 CH471078 U94831
GenPept AAC51782 AAH10856 CAD61879 CAD61941 EAW66073 EAW66075 EAW66076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca