Homo sapiens Protein: STK16 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-236864.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | STK16 | ||||||||||||||||||
Protein Name | serine/threonine kinase 16 | ||||||||||||||||||
Synonyms | KRCT; MPSK; PKL12; TSF1; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000379964 | ||||||||||||||||||
InnateDB Gene | IDBG-81446 (STK16) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. {ECO:0000269PubMed:10364453}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associates with Golgi and Golgi-derived vesicles. {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Ubiquitously expressed at very low levels. {ECO:0000269PubMed:10364453}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | O75716 | ||||||||||||||||||
PhosphoSite | PhosphoSite-O75716 | ||||||||||||||||||
TrEMBL | A0A024R440 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 8576 | ||||||||||||||||||
UniGene | Hs.600249 | ||||||||||||||||||
RefSeq | |||||||||||||||||||
HUGO | HGNC:11394 | ||||||||||||||||||
OMIM | 604719 | ||||||||||||||||||
CCDS | CCDS42822 | ||||||||||||||||||
HPRD | 05281 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB020739 AF060798 AF203910 AJ005791 AJ010872 AK292694 BC002618 BC053998 BT019585 CH471063 CR407675 | ||||||||||||||||||
GenPept | AAC28337 AAG23728 AAH02618 AAH53998 AAV38392 BAB16311 BAF85383 CAA06700 CAA09387 CAG28603 EAW70714 EAW70717 | ||||||||||||||||||