InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IQGAP2

Summary

InnateDB Protein

IDBP-237917.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IQGAP2

Protein Name

IQ motif containing GTPase activating protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000379535

InnateDB Gene

IDBG-29509 (IQGAP2)

Protein Structure

UniProt Annotation

Function

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 2 expression is enhanced in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005095	GTPase inhibitor activity
GO:0005096	GTPase activator activity
GO:0005099	Ras GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032320	positive regulation of Ras GTPase activity
GO:0043086	negative regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005874	microtubule
GO:0015629	actin cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000593 RasGAP protein, C-terminal
IPR001202 WW domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF03836
PF00397
PF00616

PRINTS

PIRSF

SMART

SM00015
SM00456
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13576