Homo sapiens Protein: DDX39B | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-238045.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | DDX39B | ||||||||||||||||||||||||||
Protein Name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | ||||||||||||||||||||||||||
Synonyms | BAT1; D6S81E; UAP56; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000379475 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-77725 (DDX39B) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription- independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability.Splice factor that is required for the first ATP- dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. | ||||||||||||||||||||||||||
Subcellular Localization | Nucleus. Nucleus speckle. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1. TREX complex assembly seems to occur in regions surrounding nuclear speckles known as perispeckles. | ||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR001650
Helicase, C-terminal IPR006935 Helicase/UvrB domain IPR011545 DEAD/DEAH box helicase domain IPR014001 Helicase, superfamily 1/2, ATP-binding domain IPR014014 RNA helicase, DEAD-box type, Q motif IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00271
PF04851 PF00270 |
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PRINTS | |||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||
SMART |
SM00490
SM00487 |
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TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | Q13838 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q13838 | ||||||||||||||||||||||||||
TrEMBL | Q7KYK3 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 7919 | ||||||||||||||||||||||||||
UniGene | Hs.635791 | ||||||||||||||||||||||||||
RefSeq | NP_004631 | ||||||||||||||||||||||||||
HUGO | HGNC:13917 | ||||||||||||||||||||||||||
OMIM | 142560 | ||||||||||||||||||||||||||
CCDS | CCDS4697 | ||||||||||||||||||||||||||
HPRD | 00805 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AB088115 AB103621 AB202112 AF029061 AF029062 AK222912 AL662801 AL662847 BA000025 BC000361 BC013006 BT009909 BX001040 BX248516 BX927320 CH471081 CR753820 CR753864 Y14768 Z37166 | ||||||||||||||||||||||||||
GenPept | AAB94615 AAC63046 AAH00361 AAH13006 AAP88911 BAB63306 BAC54953 BAD96632 BAE78637 BAF31287 CAA75074 CAA85523 CAI17664 CAI17665 CAI18279 CAI18280 CAI18281 CAI18282 CAI18283 CAI18634 CAI41922 CAQ07176 CAQ09974 CAQ10634 EAX03404 EAX03407 EAX03408 EAX03409 EAX03410 EAX03411 EAX03413 | ||||||||||||||||||||||||||