InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGB1

Summary

InnateDB Protein

IDBP-238288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGB1

Protein Name

integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

Synonyms

CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB;

Species

Homo sapiens

Ensembl Protein

ENSP00000379350

InnateDB Gene

IDBG-68302 (ITGB1)

Protein Structure

UniProt Annotation

Function

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. {ECO:0000269PubMed:12473654, ECO:0000269PubMed:16256741, ECO:0000269PubMed:17956333, ECO:0000269PubMed:18804435, ECO:0000269PubMed:19064666, ECO:0000269PubMed:21768292, ECO:0000269PubMed:7523423}.Isoform 5: Isoform 5 displaces isoform 1 in striated muscles. {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner.Isoform 5: Cell membrane, sarcolemma {ECO:0000250}. Cell junction {ECO:0000250}. Note=In cardiac muscle, isoform 5 is found in costameres and intercalated disks. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non- proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle). {ECO:0000269PubMed:1551917, ECO:0000269PubMed:2249781, ECO:0000269PubMed:7544298, ECO:0000269PubMed:7545396, ECO:0000269PubMed:7681433, ECO:0000269PubMed:9494094}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	128 [view]
Protein-Protein	127 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0001948	glycoprotein binding
GO:0001968	fibronectin binding
GO:0002020	protease binding
GO:0003779	actin binding
GO:0004872	receptor activity
GO:0005102	receptor binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0042277	peptide binding
GO:0043236	laminin binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050839	cell adhesion molecule binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001701	in utero embryonic development
GO:0001708	cell fate specification
GO:0001894	tissue homeostasis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0006874	cellular calcium ion homeostasis
GO:0006968	cellular defense response
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007161	calcium-independent cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008354	germ cell migration
GO:0009615	response to virus
GO:0010811	positive regulation of cell-substrate adhesion
GO:0010976	positive regulation of neuron projection development
GO:0014823	response to activity
GO:0016032	viral process
GO:0016477	cell migration
GO:0021943	formation of radial glial scaffolds
GO:0030183	B cell differentiation
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0031175	neuron projection development
GO:0031345	negative regulation of cell projection organization
GO:0031589	cell-substrate adhesion
GO:0031667	response to nutrient levels
GO:0032594	protein transport within lipid bilayer
GO:0033631	cell-cell adhesion mediated by integrin
GO:0034329	cell junction assembly
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045214	sarcomere organization
GO:0045596	negative regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045807	positive regulation of endocytosis
GO:0048675	axon extension
GO:0048738	cardiac muscle tissue development
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response
GO:0050900	leukocyte migration
GO:0051726	regulation of cell cycle
GO:0055007	cardiac muscle cell differentiation
GO:0060135	maternal process involved in female pregnancy
GO:0070830	tight junction assembly
GO:0071260	cellular response to mechanical stimulus
GO:0071305	cellular response to vitamin D
GO:0071479	cellular response to ionizing radiation
GO:0071559	response to transforming growth factor beta
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0001669	acrosomal vesicle
GO:0001726	ruffle
GO:0005604	basement membrane
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030056	hemidesmosome
GO:0030175	filopodium
GO:0031594	neuromuscular junction
GO:0032154	cleavage furrow
GO:0032587	ruffle membrane
GO:0034667	integrin alpha3-beta1 complex
GO:0034677	integrin alpha7-beta1 complex
GO:0034678	alpha8-beta1 integrin complex
GO:0034679	alpha9-beta1 integrin complex
GO:0035748	myelin sheath abaxonal region
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0045202	synapse
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR014836 Integrin beta subunit, cytoplasmic domain
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM

PF00092
PF00362
PF07965
PF07974
PF08725

PRINTS

PR01186

PIRSF

PIRSF002512

SMART

SM00327
SM00187
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References