InnateDB Protein
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IDBP-238647.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NCOR1
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Protein Name
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nuclear receptor corepressor 1
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Synonyms
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hN-CoR; N-CoR; N-CoR1; PPP1R109; TRAC1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000379192
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InnateDB Gene
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IDBG-31971 (NCOR1)
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Protein Structure
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Function |
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. {ECO:0000269PubMed:14527417}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00624}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 236 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
236
[view]
|
Protein-Protein |
223
[view]
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Protein-DNA |
10
[view]
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Protein-RNA |
0
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DNA-DNA |
3
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0007179
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transforming growth factor beta receptor signaling pathway
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GO:0007219
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Notch signaling pathway
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GO:0010467
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gene expression
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GO:0016568
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chromatin modification
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0046329
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negative regulation of JNK cascade
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GO:0051225
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spindle assembly
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GO:0072362
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regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter
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GO:0072368
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regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
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GO:2000191
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regulation of fatty acid transport
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Cellular Component |
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PDB ID |
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InterPro |
IPR001005
SANT/Myb domain
IPR009057
Homeodomain-like
IPR017877
Myb-like domain
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PFAM |
PF00249
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PRINTS |
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PIRSF |
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SMART |
SM00717
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TIGRFAMs |
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Modification |
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SwissProt |
O75376
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PhosphoSite |
PhosphoSite-O75376
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TrEMBL |
C9JAP0
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UniProt Splice Variant |
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Entrez Gene |
9611
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UniGene |
Hs.666008
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RefSeq |
NP_001177369
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HUGO |
HGNC:7672
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OMIM |
600849
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CCDS |
CCDS54095
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HPRD |
02911
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IMGT |
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EMBL |
AB019524
AB028970
AC002553
AC005971
AF044209
AF303586
BC167431
CH471222
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GenPept |
AAC33550
AAI67431
AAO32942
BAA75814
BAA82999
EAX04494
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