Version 5.4
Homo sapiens Protein: TOM1L2
Summary
InnateDB Protein IDBP-238934.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOM1L2
Protein Name target of myb1-like 2 (chicken)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000379088
InnateDB Gene IDBG-33308 (TOM1L2)
Protein Structure
UniProt Annotation
Function Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. {ECO:0000269PubMed:16412388, ECO:0000269PubMed:16479011}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitously expressed with higher expression in heart and skeletal muscle. {ECO:0000269PubMed:11997338}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0030276 clathrin binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0045839 negative regulation of mitosis
Cellular Component
GO:0005622 intracellular
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002014 VHS
IPR004152 GAT
IPR008942 ENTH/VHS
IPR014645 Target of Myb protein 1
IPR018205 VHS subgroup
PFAM PF00790
PF03127
PRINTS
PIRSF PIRSF036948
SMART SM00288
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZVM7
PhosphoSite PhosphoSite-Q6ZVM7
TrEMBL K7ENB0
UniProt Splice Variant
Entrez Gene 146691
UniGene Hs.739326
RefSeq
HUGO HGNC:11984
OMIM 615519
CCDS CCDS74002
HPRD 18213
IMGT
EMBL AC087163 AC122129 AF467441 AK057308 AK124331 AK301944 BC051650
GenPept AAH51650 AAL78338 BAB71421 BAC85834 BAH13590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca