InnateDB Protein
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IDBP-239249.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC47A1
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Protein Name
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solute carrier family 47, member 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378951
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InnateDB Gene
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IDBG-34817 (SLC47A1)
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Protein Structure
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Function |
Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. {ECO:0000269PubMed:16330770, ECO:0000269PubMed:16996621, ECO:0000269PubMed:17495125, ECO:0000269PubMed:17509534, ECO:0000269PubMed:17582384}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:16330770, ECO:0000269PubMed:16641166}; Multi-pass membrane protein {ECO:0000269PubMed:16330770, ECO:0000269PubMed:16641166}. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.
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Disease Associations |
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Tissue Specificity |
Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes). {ECO:0000269PubMed:16330770, ECO:0000269PubMed:17509534}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002528
Multi antimicrobial extrusion protein
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PFAM |
PF01554
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96FL8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55244
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UniGene |
Hs.603255
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RefSeq |
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HUGO |
HGNC:25588
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OMIM |
609832
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CCDS |
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HPRD |
07703
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IMGT |
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EMBL |
AK001709
AK222625
BC010661
BC050592
BC058882
CH471212
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GenPept |
AAH10661
AAH50592
AAH58882
BAA91852
BAD96345
EAW50893
EAW50894
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