Version 5.4
Homo sapiens Protein: WDR6
Summary
InnateDB Protein IDBP-239482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR6
Protein Name WD repeat domain 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000378857
InnateDB Gene IDBG-33969 (WDR6)
Protein Structure
UniProt Annotation
Function Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269PubMed:17216128, ECO:0000269PubMed:22354037}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17216128}. Note=Colocalizes in the cytoplasm with STK11/LKB1.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:10903905}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043560 insulin receptor substrate binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0010507 negative regulation of autophagy
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008180 COP9 signalosome
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9NNW5
TrEMBL V9GZ65
UniProt Splice Variant
Entrez Gene 11180
UniGene Hs.694641
RefSeq XP_005264894
HUGO HGNC:12758
OMIM 606031
CCDS CCDS2782
HPRD 06912
IMGT
EMBL AC137630 AF099100 AK295145 AL133589 AL833910 BC002826 BC078176 BC101707 BC113467
GenPept AAF80244 AAH02826 AAH78176 AAI01708 AAI13468 BAG58164 CAB63730 CAD38766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca