Version 5.4
Homo sapiens Protein: SLC6A4
Summary
InnateDB Protein IDBP-240808.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A4
Protein Name solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms 5-HTT; 5-HTTLPR; 5HTT; hSERT; HTT; OCD1; SERT; SERT1;
Species Homo sapiens
Ensembl Protein ENSP00000378298
InnateDB Gene IDBG-38865 (SLC6A4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005335 serotonin:sodium symporter activity
Biological Process
GO:0006836 neurotransmitter transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR013086 Sodium:neurotransmitter symporter, serotonin, N-terminal
PFAM PF00209
PF03491
PRINTS PR00176
PR01203
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9NYN7
UniProt Splice Variant
Entrez Gene 6532
UniGene Hs.29792
RefSeq
HUGO HGNC:11050
OMIM 182138
CCDS
HPRD 01640
IMGT
EMBL AC104984 AF233399 EU796564 EU796569 EU796574 EU796579 EU796584 EU796589 EU796594 EU796604 EU796614 EU796619 EU796624
GenPept AAF61945 ACE96158 ACE96163 ACE96168 ACE96178 ACE96188 ACE96193 ACE96198 ACE96203 ACE96208 ACE96213 ACE96218

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca