InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBCK

Summary

InnateDB Protein

IDBP-241014.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBCK

Protein Name

TBC1 domain containing kinase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000378196

InnateDB Gene

IDBG-33156 (TBCK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005097	Rab GTPase activator activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000195 Rab-GTPase-TBC domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001763 Rhodanese-like domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00566
PF00069
PF07714
PF00581

PRINTS

PR00109

PIRSF

SMART

SM00164
SM00450
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt