InnateDB Protein
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IDBP-241067.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BRD7
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Protein Name
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bromodomain containing 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000378181
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InnateDB Gene
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IDBG-30500 (BRD7)
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Protein Structure
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Function |
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269PubMed:16265664, ECO:0000269PubMed:16475162, ECO:0000269PubMed:20215511, ECO:0000269PubMed:20228809, ECO:0000269PubMed:20660729}.
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Subcellular Localization |
Isoform 2: Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
62
[view]
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Protein-Protein |
62
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0007049
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cell cycle
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GO:0008285
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negative regulation of cell proliferation
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GO:0016055
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Wnt signaling pathway
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GO:0035066
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positive regulation of histone acetylation
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:2000134
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negative regulation of G1/S transition of mitotic cell cycle
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Cellular Component |
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PDB ID |
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InterPro |
IPR001487
Bromodomain
IPR021900
Protein of unknown function DUF3512
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PFAM |
PF00439
PF12024
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PRINTS |
PR00503
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PIRSF |
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SMART |
SM00297
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NPI1
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PhosphoSite |
PhosphoSite-Q9NPI1
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TrEMBL |
I3L4V5
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UniProt Splice Variant |
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Entrez Gene |
29117
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UniGene |
Hs.708878
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RefSeq |
NP_001167455
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HUGO |
HGNC:14310
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OMIM |
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CCDS |
CCDS54007
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HPRD |
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IMGT |
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EMBL |
AC007493
AC007597
AC023826
AF152604
AF213969
AJ271881
AK027308
AK074613
BC001611
BC050728
BC094706
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GenPept |
AAF19526
AAF75126
AAH01611
AAH50728
AAH94706
BAB55031
BAC11089
CAB72445
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