InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GTF2F1

Summary

InnateDB Protein

IDBP-241544.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GTF2F1

Protein Name

general transcription factor IIF, polypeptide 1, 74kDa

Synonyms

BTF4; RAP74; TF2F1; TFIIF;

Species

Homo sapiens

Ensembl Protein

ENSP00000377969

InnateDB Gene

IDBG-21234 (GTF2F1)

Protein Structure

UniProt Annotation

Function

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. {ECO:0000269PubMed:10428810}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	82 [view]
Protein-Protein	81 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019211	phosphatase activator activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0008380	RNA splicing
GO:0009615	response to virus
GO:0010467	gene expression
GO:0016032	viral process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043085	positive regulation of catalytic activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription