Homo sapiens Protein: QRFPR
Summary
InnateDB Protein IDBP-241616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol QRFPR
Protein Name pyroglutamylated RFamide peptide receptor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000377948
InnateDB Gene IDBG-36128 (QRFPR)
Protein Structure
UniProt Annotation
Function Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels. {ECO:0000269PubMed:12960173}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid. {ECO:0000269PubMed:11574155, ECO:0000269PubMed:12714592}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR005395 Neuropeptide FF receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR01012
PR01570
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96P65
PhosphoSite PhosphoSite-Q96P65
TrEMBL
UniProt Splice Variant
Entrez Gene 84109
UniGene Hs.368977
RefSeq NP_937822
HUGO HGNC:15565
OMIM 606925
CCDS CCDS3719
HPRD 09494
IMGT
EMBL AB109629 AF411117
GenPept AAL26488 BAC98938