Version 5.4
Homo sapiens Protein: PPP2R2B
Summary
InnateDB Protein IDBP-241648.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R2B
Protein Name protein phosphatase 2, regulatory subunit B, beta
Synonyms B55BETA; PP2AB55BETA; PP2ABBETA; PP2APR55B; PP2APR55BETA; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B; PR55-BETA; PR55BETA; SCA12;
Species Homo sapiens
Ensembl Protein ENSP00000377931
InnateDB Gene IDBG-52116 (PPP2R2B)
Protein Structure
UniProt Annotation
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity). {ECO:0000250}.
Subcellular Localization Isoform 1: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}.Isoform 2: Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). {ECO:0000250}.
Disease Associations Spinocerebellar ataxia 12 (SCA12) [MIM:604326]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA). {ECO:0000269PubMed:10581021}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
Experimentally validated
Total 53 [view]
Protein-Protein 51 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000009 Protein phosphatase 2A, regulatory subunit PR55
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS PR00600
PIRSF PIRSF037309
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q00005
PhosphoSite PhosphoSite-Q00005
TrEMBL Q9NS07
UniProt Splice Variant
Entrez Gene 5521
UniGene Hs.739387
RefSeq
HUGO HGNC:9305
OMIM 604325
CCDS
HPRD 05059
IMGT
EMBL AC008728 AC009186 AC010251 AC011357 AC011386 AC091919 AC091924 AF152102 AK056192 AK289717 AK294659 AK295347 BC031790 BI490027 BI669304 CH471062 M64930
GenPept AAA36493 AAF74024 AAH31790 BAF82406 BAG51642 BAH11838 BAH12040 EAW61829 EAW61831 EAW61832 EAW61833 EAW61834 EAW61835

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca