InnateDB Protein
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IDBP-241745.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TARBP2
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Protein Name
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TAR (HIV-1) RNA binding protein 2
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Synonyms
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LOQS; TRBP; TRBP1; TRBP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377885
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InnateDB Gene
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IDBG-36938 (TARBP2)
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Protein Structure
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Function |
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. {ECO:0000269PubMed:12475984, ECO:0000269PubMed:15973356, ECO:0000269PubMed:16142218, ECO:0000269PubMed:16271387, ECO:0000269PubMed:16357216, ECO:0000269PubMed:16424907, ECO:0000269PubMed:17452327, ECO:0000269PubMed:18178619, ECO:0000269PubMed:19219043}.
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Subcellular Localization |
Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
57
[view]
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Protein-Protein |
56
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006417
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regulation of translation
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GO:0006469
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negative regulation of protein kinase activity
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GO:0010467
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gene expression
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GO:0030422
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production of siRNA involved in RNA interference
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GO:0030423
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targeting of mRNA for destruction involved in RNA interference
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GO:0031054
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pre-miRNA processing
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GO:0035280
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miRNA loading onto RISC involved in gene silencing by miRNA
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GO:0045070
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positive regulation of viral genome replication
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GO:0046782
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regulation of viral transcription
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GO:0050689
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negative regulation of defense response to virus by host
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Cellular Component |
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PDB ID |
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InterPro |
IPR014720
Double-stranded RNA-binding domain
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PFAM |
PF00035
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PRINTS |
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PIRSF |
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SMART |
SM00358
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TIGRFAMs |
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Modification |
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SwissProt |
Q15633
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PhosphoSite |
PhosphoSite-Q15633
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TrEMBL |
H3BV98
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UniProt Splice Variant |
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Entrez Gene |
6895
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UniGene |
Hs.326
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RefSeq |
NP_599151
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HUGO |
HGNC:11569
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OMIM |
605053
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CCDS |
CCDS41791
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HPRD |
05446
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IMGT |
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EMBL |
AC023509
AF281068
BC005860
BT007140
CH471054
M60801
U08998
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GenPept |
AAA36765
AAB50581
AAH05860
AAL55730
AAL55731
AAP35804
EAW96718
EAW96719
EAW96720
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