InnateDB Protein
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IDBP-242013.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DENND1A
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Protein Name
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DENN/MADD domain containing 1A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377763
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InnateDB Gene
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IDBG-84620 (DENND1A)
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Protein Structure
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Function |
Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles. {ECO:0000269PubMed:20154091, ECO:0000269PubMed:20937701}.
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Subcellular Localization |
Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269PubMed:20937701}; Peripheral membrane protein {ECO:0000269PubMed:20937701}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269PubMed:20937701}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0017112
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Rab guanyl-nucleotide exchange factor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001194
DENN domain
IPR005112
dDENN domain
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PFAM |
PF02141
PF03455
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PRINTS |
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PIRSF |
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SMART |
SM00799
SM00801
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TEH3
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PhosphoSite |
PhosphoSite-Q8TEH3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57706
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UniGene |
Hs.682912
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RefSeq |
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HUGO |
HGNC:29324
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OMIM |
613633
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CCDS |
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HPRD |
17221
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IMGT |
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EMBL |
AC006450
AK024782
AK074151
AK295710
AK299867
AL161790
AL390774
AL445489
BC009616
BC028061
BC039703
BK006958
CH471090
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GenPept |
AAH09616
AAH28061
AAH39703
BAB15002
BAB84977
BAH12164
BAH13155
CAH73637
CAH73638
CAH73640
CAI15705
CAI15706
CAI15707
CAI39791
CAI39792
CAI39794
DAA12500
EAW87571
EAW87575
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