InnateDB Protein
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IDBP-242078.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IKZF3
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Protein Name
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IKAROS family zinc finger 3 (Aiolos)
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Synonyms
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AIO; AIOLOS; ZNFN1A3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377741
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InnateDB Gene
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IDBG-46313 (IKZF3)
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Protein Structure
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Function |
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2- dependent manner. {ECO:0000269PubMed:10369681}.
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Subcellular Localization |
Nucleus. Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. {ECO:0000269PubMed:17646674}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
39
[view]
|
Protein-Protein |
37
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR015880
Zinc finger, C2H2-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UKT9
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PhosphoSite |
PhosphoSite-Q9UKT9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22806
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UniGene |
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RefSeq |
NP_001244341
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HUGO |
HGNC:13178
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OMIM |
606221
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CCDS |
CCDS58542
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HPRD |
05869
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IMGT |
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EMBL |
AC079199
AC090844
AF129512
AJ292565
AJ292566
AJ292567
AJ292568
AJ292569
AK301250
AK303495
AY377973
AY377975
AY377976
AY377977
AY377978
AY377979
AY377980
AY377981
AY377982
BC032707
CH471152
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GenPept |
AAF13493
AAH32707
AAR84584
AAR84586
AAR84587
AAR84588
AAR84589
AAR84590
AAR84591
AAR84592
AAR84593
BAG62817
BAG64529
CAC80427
CAC80428
CAC80429
CAC80430
CAC80431
EAW60606
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