InnateDB Protein
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IDBP-242134.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDH11
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Protein Name
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cadherin 11, type 2, OB-cadherin (osteoblast)
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Synonyms
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CAD11; CDHOB; OB; OSF-4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377711
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InnateDB Gene
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IDBG-34793 (CDH11)
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Protein Structure
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Function |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein.
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Disease Associations |
Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.
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Tissue Specificity |
Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002126
Cadherin
IPR015919
Cadherin-like
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PFAM |
PF00028
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PRINTS |
PR00205
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PIRSF |
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SMART |
SM00112
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TIGRFAMs |
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Modification |
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SwissProt |
P55287
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PhosphoSite |
PhosphoSite-P55287
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TrEMBL |
H3BSM4
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UniProt Splice Variant |
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Entrez Gene |
1009
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UniGene |
Hs.116471
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RefSeq |
XP_005255821
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HUGO |
HGNC:1750
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OMIM |
600023
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CCDS |
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HPRD |
08960
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IMGT |
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EMBL |
AC010533
AC137643
AF060369
AF060370
AK291251
D21254
D21255
L34056
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GenPept |
AAA35622
AAD27755
AAD27756
BAA04798
BAA04799
BAF83940
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