InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNP

Summary

InnateDB Protein

IDBP-242706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNP

Protein Name

2',3'-cyclic nucleotide 3' phosphodiesterase

Synonyms

CNP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000377470

InnateDB Gene

IDBG-50122 (CNP)

Protein Structure

UniProt Annotation

Function

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. {ECO:0000250}.

Subcellular Localization

Membrane; Lipid-anchor. Melanosome. Note=Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004113	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0030551	cyclic nucleotide binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0007268	synaptic transmission
GO:0007409	axonogenesis
GO:0007568	aging
GO:0008344	adult locomotory behavior
GO:0009214	cyclic nucleotide catabolic process
GO:0009636	response to toxic substance
GO:0021762	substantia nigra development
GO:0030900	forebrain development
GO:0032496	response to lipopolysaccharide
GO:0046902	regulation of mitochondrial membrane permeability
GO:0048709	oligodendrocyte differentiation

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0016020	membrane
GO:0031143	pseudopodium
GO:0035748	myelin sheath abaxonal region
GO:0035749	myelin sheath adaxonal region
GO:0042470	melanosome
GO:0042995	cell projection
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR008431 Cyclic nucleotide phosphodiesterase
IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase
IPR010488 Zeta toxin domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF05881
PF06414

PRINTS

PIRSF

PIRSF000970

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P09543