InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YBX2

Summary

InnateDB Protein

IDBP-24281.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YBX2

Protein Name

Y box binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000007699

InnateDB Gene

IDBG-24279 (YBX2)

Protein Structure

UniProt Annotation

Function

Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16479255}. Nucleus {ECO:0000269PubMed:16479255}.

Disease Associations

Tissue Specificity

Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level). {ECO:0000269PubMed:10100484, ECO:0000269PubMed:16479255}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0008289	lipid binding
GO:0043021	ribonucleoprotein complex binding
GO:0045182	translation regulator activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0009386	translational attenuation
GO:0017148	negative regulation of translation
GO:0048255	mRNA stabilization
GO:0048477	oogenesis
GO:0048599	oocyte development
GO:0051100	negative regulation of binding