InnateDB Protein
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IDBP-243624.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HNRNPH1
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Protein Name
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heterogeneous nuclear ribonucleoprotein H1 (H)
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Synonyms
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hnRNPH; HNRPH; HNRPH1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000377082
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InnateDB Gene
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IDBG-61485 (HNRNPH1)
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Protein Structure
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Function |
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269PubMed:11003644, ECO:0000269PubMed:16946708}.
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Subcellular Localization |
Nucleus, nucleoplasm.
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Disease Associations |
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Tissue Specificity |
Expressed ubiquitously.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
161
[view]
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Protein-Protein |
161
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR012996
Zinc finger, CHHC-type
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PFAM |
PF00076
PF08080
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P31943
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PhosphoSite |
PhosphoSite-P31943
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TrEMBL |
Q68DG4
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UniProt Splice Variant |
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Entrez Gene |
3187
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UniGene |
Hs.695152
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RefSeq |
NP_001244222
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HUGO |
HGNC:5041
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OMIM |
601035
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CCDS |
CCDS4446
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HPRD |
03021
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IMGT |
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EMBL |
AC136604
AK124530
BC001348
CH471165
CR456778
CR749414
L22009
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GenPept |
AAA91346
AAH01348
BAG54048
CAG33059
CAH18256
EAW53807
EAW53808
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