Homo sapiens Protein: NUP98
InnateDB Protein IDBP-24391.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUP98
Protein Name nucleoporin 98kDa
Synonyms ADIR2; NUP196; NUP96;
Species Homo sapiens
Ensembl Protein ENSP00000347404
InnateDB Gene IDBG-24385 (NUP98)
Protein Structure
UniProt Annotation
Function Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. {ECO:0000269PubMed:15229283}.
Subcellular Localization Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Note=Nup96 is localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket. Dissociates from the dissasembled NPC structure early during prophase of mitosis. Colocalized with NUP153 and TPR to the nuclear basket of NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection.
Disease Associations Note=A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23. {ECO:0000269PubMed:16028218}.Note=A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. {ECO:0000269PubMed:16028218}.Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. {ECO:0000269PubMed:16028218}.Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. {ECO:0000269PubMed:16028218}.Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. {ECO:0000269PubMed:16028218}.Note=A chromosomal aberration involving NUP98 has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with CCDC28A. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98- CCDC28A in mouse promotes the proliferative capacity and self- renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage. {ECO:0000269PubMed:16028218}.
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 60 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0017056 structural constituent of nuclear pore
Biological Process
GO:0000059 protein import into nucleus, docking
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0006260 DNA replication
GO:0006810 transport
GO:0006913 nucleocytoplasmic transport
GO:0006999 nuclear pore organization
GO:0007077 mitotic nuclear envelope disassembly
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0044281 small molecule metabolic process
GO:0051028 mRNA transport
GO:0051292 nuclear pore complex assembly
GO:0055085 transmembrane transport
Cellular Component
GO:0000776 kinetochore
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0031080 nuclear pore outer ring
GO:0031965 nuclear membrane
GO:0034399 nuclear periphery
GO:0042405 nuclear inclusion body
GO:0044615 nuclear pore nuclear basket
Protein Structure and Domains
InterPro IPR007230 Peptidase S59, nucleoporin
IPR021967 Nuclear protein 96
PFAM PF04096
Post-translational Modifications
SwissProt P52948
PhosphoSite PhosphoSite-P52948
UniProt Splice Variant
Entrez Gene 4928
UniGene Hs.524750
RefSeq NP_624358
OMIM 601021
HPRD 03012
EMBL AB038344 AB040538 AC060812 AC090587 AF071076 AF071077 AF116074 AF231130 AL133601 AL137613 BC012906 BC041136 BT007349 U41815
GenPept AAC50366 AAD22395 AAD22396 AAF19342 AAH12906 AAH41136 AAL56659 AAP36013 BAB11850 BAB18537 CAB63736 CAB70842