Version 5.4
Homo sapiens Protein: IL1F10
Summary
InnateDB Protein IDBP-244129.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1F10
Protein Name interleukin 1 family, member 10 (theta)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000376893
InnateDB Gene IDBG-66783 (IL1F10)
Protein Structure
UniProt Annotation
Function Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2. {ECO:0000269PubMed:22315422}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
Biological Process
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000975 Interleukin-1 family
IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
IPR008996 Cytokine, IL-1-like
PFAM PF00340
PRINTS PR00264
PR01360
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WWZ1
PhosphoSite PhosphoSite-Q8WWZ1
TrEMBL
UniProt Splice Variant
Entrez Gene 84639
UniGene Hs.306974
RefSeq NP_115945
HUGO HGNC:15552
OMIM 615296
CCDS CCDS2112
HPRD 17144
IMGT
EMBL AC016724 AF334755 AF334756 AY026753 AY029413 AY358846 AY972854 BC103966 BC103967 BC103968 BN000002
GenPept AAI03967 AAI03968 AAI03969 AAK01948 AAK33010 AAK68048 AAK68049 AAQ89205 AAX59032 AAY14991 CAD29878

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca