InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPO

Summary

InnateDB Protein

IDBP-244405.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPO

Protein Name

thymopoietin

Synonyms

CMD1T; LAP2; LEMD4; PRO0868; TP;

Species

Homo sapiens

Ensembl Protein

ENSP00000376773

InnateDB Gene

IDBG-52209 (TMPO)

Protein Structure

UniProt Annotation

Function

May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Subcellular Localization

Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.Isoform Zeta: Cytoplasm {ECO:0000269PubMed:18403046}.

Disease Associations

Tissue Specificity

Expressed in many tissues. Most abundant in adult thymus and fetal liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	65 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0005521	lamin binding

Biological Process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane