InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIAS3

Summary

InnateDB Protein

IDBP-244417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIAS3

Protein Name

protein inhibitor of activated STAT, 3

Synonyms

ZMIZ5;

Species

Homo sapiens

Ensembl Protein

ENSP00000376765

InnateDB Gene

IDBG-101753 (PIAS3)

Protein Structure

UniProt Annotation

Function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. {ECO:0000269PubMed:21965678, ECO:0000269PubMed:9388184}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Mainly cytoplasmic but shuttles between the nucleus and cytoplasm. Transported to the nucleus on interaction with phosphorylated STAT3. Colocalizes with GFI1 in nuclear dots (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. {ECO:0000269PubMed:9388184}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	75 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008270	zinc ion binding
GO:0015459	potassium channel regulator activity
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009725	response to hormone
GO:0010628	positive regulation of gene expression
GO:0016925	protein sumoylation
GO:0033235	positive regulation of protein sumoylation
GO:0045838	positive regulation of membrane potential