InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR17

Summary

InnateDB Protein

IDBP-244476.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR17

Protein Name

G protein-coupled receptor 17

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000376741

InnateDB Gene

IDBG-69246 (GPR17)

Protein Structure

UniProt Annotation

Function

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. {ECO:0000269PubMed:16990797}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain. {ECO:0000269PubMed:16990797}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003912 Protease-activated receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01428

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13304