InnateDB Protein
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IDBP-245088.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AMZ2
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Protein Name
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archaelysin family metallopeptidase 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376481
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InnateDB Gene
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IDBG-65751 (AMZ2)
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Protein Structure
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Function |
Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2. {ECO:0000269PubMed:15972818}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in heart and testis. Also expressed at lower levels in kidney, liver, pancreas, lung, brain and placenta. Expressed in fetal tissues such as kidney, liver, lung and brain. Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS). {ECO:0000269PubMed:15972818, ECO:0000269PubMed:17074343}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR012962
Peptidase M54, archaemetzincin
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PFAM |
PF07998
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86W34
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PhosphoSite |
PhosphoSite-Q86W34
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TrEMBL |
J3QLK6
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UniProt Splice Variant |
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Entrez Gene |
51321
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UniGene |
Hs.293560
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RefSeq |
XP_005257489
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HUGO |
HGNC:28041
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OMIM |
615169
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CCDS |
CCDS11674
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HPRD |
14237
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IMGT |
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EMBL |
AC005332
AF208856
AJ635358
AK090981
AK126146
BC050709
BC056271
CH471099
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GenPept |
AAF64270
AAH50709
AAH56271
BAC86462
BAG52256
CAG25750
EAW89050
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