InnateDB Protein
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IDBP-245211.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGAP32
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Protein Name
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Rho GTPase activating protein 32
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Synonyms
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GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS; RICS;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376425
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InnateDB Gene
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IDBG-76010 (ARHGAP32)
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Protein Structure
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Function |
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine {ECO:0000250}. Cytoplasm, cell cortex. Endosome membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Membrane. Note=Association to membrane via PX domain. Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment. Colocalizes with GAB2 at the cell membrane. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen. {ECO:0000269PubMed:12446789}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
43
[view]
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Protein-Protein |
42
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0007165
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signal transduction
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GO:0007264
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small GTPase mediated signal transduction
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GO:0043547
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positive regulation of GTPase activity
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GO:0051056
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regulation of small GTPase mediated signal transduction
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Cellular Component |
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PDB ID |
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InterPro |
IPR000198
Rho GTPase-activating protein domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00620
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PRINTS |
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PIRSF |
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SMART |
SM00324
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TIGRFAMs |
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Modification |
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SwissProt |
A7KAX9
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PhosphoSite |
PhosphoSite-A7KAX9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9743
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UniGene |
Hs.594618
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RefSeq |
NP_055530
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HUGO |
HGNC:17399
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OMIM |
608541
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CCDS |
CCDS31718
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HPRD |
12257
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IMGT |
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EMBL |
AB018255
AB079856
AB088416
AY194287
BC000277
BC104898
BC113429
CH471065
EF127492
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GenPept |
AAH00277
AAI04899
AAI13430
AAO43677
ABO33171
BAA34432
BAC24802
BAM34446
EAW67740
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