InnateDB Protein
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IDBP-245520.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DYNLL1
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Protein Name
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dynein, light chain, LC8-type 1
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Synonyms
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DLC1; DLC8; DNCL1; DNCLC1; hdlc1; LC8; LC8a; PIN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000376297
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InnateDB Gene
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IDBG-60661 (DYNLL1)
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Protein Structure
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Function |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:8628263}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 131 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
131
[view]
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Protein-Protein |
131
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001372
Dynein light chain, type 1/2
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PFAM |
PF01221
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P63167
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PhosphoSite |
PhosphoSite-P63167
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TrEMBL |
Q6FGH9
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UniProt Splice Variant |
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Entrez Gene |
8655
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UniGene |
Hs.5120
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RefSeq |
NP_001032583
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HUGO |
HGNC:15476
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OMIM |
601562
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CCDS |
CCDS9200
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HPRD |
03334
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IMGT |
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EMBL |
AC063943
AK311790
AL021546
BC100289
BC104244
BC104245
CH471054
CR407672
CR542128
U32944
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GenPept |
AAB04149
AAI00290
AAI04245
AAI04246
BAG34733
CAG28600
CAG46925
EAW98195
EAW98196
EAW98197
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