InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AANAT

Summary

InnateDB Protein

IDBP-245551.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AANAT

Protein Name

aralkylamine N-acetyltransferase

Synonyms

DSPS; SNAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000376282

InnateDB Gene

IDBG-69711 (AANAT)

Protein Structure

UniProt Annotation

Function

Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11313340}.

Disease Associations

Delayed sleep phase syndrome (DSPS) [MIM:614163]: A circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPS have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities. {ECO:0000269PubMed:12736803}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Susceptibility to delayed sleep phase syndrome can be conferred by variant Thr-129. Thr-129 shows a significantly higher frequency in affected individuals than in healthy controls.

Tissue Specificity

Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland. {ECO:0000269PubMed:18212399, ECO:0000269PubMed:8661026}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004059	aralkylamine N-acetyltransferase activity
GO:0008080	N-acetyltransferase activity

Biological Process

GO:0006474	N-terminal protein amino acid acetylation
GO:0007623	circadian rhythm
GO:0030187	melatonin biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046219	indolalkylamine biosynthetic process
GO:0071320	cellular response to cAMP