InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PID1

Summary

InnateDB Protein

IDBP-246438.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PID1

Protein Name

phosphotyrosine interaction domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000375908

InnateDB Gene

IDBG-82721 (PID1)

Protein Structure

UniProt Annotation

Function

Increases proliferation of preadipocytes without affecting adipocytic differentiation. {ECO:0000269PubMed:16815647}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16815647}.

Disease Associations

Tissue Specificity

Expressed in subcutaneous fat, heart, skeletal muscle, brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. {ECO:0000269PubMed:16815647}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0006112	energy reserve metabolic process
GO:0010628	positive regulation of gene expression
GO:0010635	regulation of mitochondrial fusion
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0051881	regulation of mitochondrial membrane potential
GO:0070346	positive regulation of fat cell proliferation
GO:0070584	mitochondrion morphogenesis
GO:0071345	cellular response to cytokine stimulus
GO:0071354	cellular response to interleukin-6
GO:0071356	cellular response to tumor necrosis factor
GO:0071398	cellular response to fatty acid
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:0090298	negative regulation of mitochondrial DNA replication
GO:2000045	regulation of G1/S transition of mitotic cell cycle
GO:2000377	regulation of reactive oxygen species metabolic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2001170	negative regulation of ATP biosynthetic process
GO:2001171	positive regulation of ATP biosynthetic process
GO:2001274	negative regulation of glucose import in response to insulin stimulus