InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TP53BP2

Summary

InnateDB Protein

IDBP-246799.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53BP2

Protein Name

tumor protein p53 binding protein, 2

Synonyms

53BP2; ASPP2; BBP; P53BP2; PPP1R13A;

Species

Homo sapiens

Ensembl Protein

ENSP00000375750

InnateDB Gene

IDBG-106878 (TP53BP2)

Protein Structure

UniProt Annotation

Function

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. {ECO:0000269PubMed:11684014, ECO:0000269PubMed:12694406, ECO:0000269PubMed:19377511}.

Subcellular Localization

Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. {ECO:0000269PubMed:10498867, ECO:0000269PubMed:10631318, ECO:0000269PubMed:11684014}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	72 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0042802	identical protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0009967	positive regulation of signal transduction
GO:0045786	negative regulation of cell cycle
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR002110 Ankyrin repeat
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
IPR020683 Ankyrin repeat-containing domain

PFAM