InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEGS1

Summary

InnateDB Protein

IDBP-246801.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEGS1

Protein Name

degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)

Synonyms

DEGS; DEGS-1; Des-1; DES1; FADS7; MLD;

Species

Homo sapiens

Ensembl Protein

ENSP00000375749

InnateDB Gene

IDBG-106891 (DEGS1)

Protein Structure

UniProt Annotation

Function

Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). {ECO:0000269PubMed:11937514}.

Subcellular Localization

Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:9188692}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0009055	electron carrier activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Biological Process

GO:0006629	lipid metabolic process
GO:0006636	unsaturated fatty acid biosynthetic process
GO:0006665	sphingolipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane