InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFPT

Summary

InnateDB Protein

IDBP-247045.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFPT

Protein Name

TCF3 (E2A) fusion partner (in childhood Leukemia)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000375639

InnateDB Gene

IDBG-68078 (TFPT)

Protein Structure

UniProt Annotation

Function

Appears to promote apoptosis in a p53/TP53-independent manner.Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18922472}.

Disease Associations

Note=A chromosomal aberration involving TFPT is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Inversion inv(19)(p13;q13) with TCF3.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0097190	apoptotic signaling pathway