Version 5.4
Homo sapiens Protein: KIR3DL1
Summary
InnateDB Protein IDBP-247108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIR3DL1
Protein Name killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
Synonyms CD158E1; KIR; KIR3DL1/S1; NKAT-3; NKAT3; NKB1; NKB1B;
Species Homo sapiens
Ensembl Protein ENSP00000375608
InnateDB Gene IDBG-69578 (KIR3DL1)
Protein Structure
UniProt Annotation
Function Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269PubMed:22020283}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 5 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030109 HLA-B specific inhibitory MHC class I receptor activity
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR013151 Immunoglobulin
PFAM PF00047
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43629
PhosphoSite PhosphoSite-P43629
TrEMBL Q8NHL0
UniProt Splice Variant
Entrez Gene 3811
UniGene Hs.645228
RefSeq NP_037421
HUGO HGNC:6338
OMIM 604946
CCDS CCDS42621
HPRD 10034
IMGT
EMBL AC006293 AC011501 AF022049 AF262968 AY760023 FJ158650 L41269 L76664 U30273 U30274 U31416 X94262
GenPept AAA69870 AAB36592 AAB52521 AAB52522 AAB95322 AAC23725 AAK30055 AAV32436 ACJ37424 CAA63938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca